Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule.
Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry.Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity.However, the Patch Leads dependence of differences in entry efficiency on SNPs remains unclea